Tuberculosis remains the world’s deadliest infectious disease despite decades of treatment, and one of the biggest obstacles to better control has been diagnosis. Standard tests can miss many cases, while more accurate molecular methods often depend on laboratory equipment and infrastructure that is out of reach in much of the world where TB is most common.

A new portable system, MiniDock MTB, is being presented as a possible way to close that gap. According to a study in The New England Journal of Medicine, researchers from the University of California, San Francisco, and the University of California, Irvine found that the device can produce results in less than 30 minutes while matching the accuracy of established laboratory testing.

The appeal of the system is not only speed but flexibility. The technology can work with samples such as tongue swabs, which could make testing easier for children and for people living with HIV, groups that often struggle to provide sputum. University of California researchers said the battery-powered device is designed for point-of-care use and can be operated with minimal training, bringing molecular diagnostics closer to frontline clinics.

The findings have also drawn regulatory attention. The World Health Organization has issued its first recommendation for this type of test, a sign that the device could help shift TB care towards same-day diagnosis and treatment. A multicentre study involving 1,380 participants across several countries reported that MiniDock MTB met WHO accuracy targets for near-point-of-care tuberculosis testing, with strong sensitivity and specificity and good usability scores.

Early data from Indonesia further support that assessment, with researchers reporting that the device’s sensitivity exceeded the WHO threshold for a sputum-based near-point-of-care test in adults and showed close agreement with the Xpert MTB/RIF Ultra assay. If those results hold up more broadly, MiniDock MTB could become a practical option in settings where conventional laboratory testing is too slow, too costly or simply unavailable.

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Source: Noah Wire Services